- A generation ago, CLL was commonly diagnosed when patients went to see their doctor because they had symptoms from swollen nodes or enlarged spleen or low blood counts. Now, most folks are asymptomatic at time of diagnosis and it’s found on a routine blood test done for another reason, such as an annual checkup.
- Some 60% of healthy young patients, with mutated IGVH and B2M < 2.0, are in durable remissions more than 15 years out post 6 months of FCR, suggesting there still might a role for chemo-immunotherapy for a small select population.
- ROR1 is found on the surface of most CLL cells and in some other cancers, but it is hard to find on any normal tissues, making it a good target for CLL treatments. ROR1 is common in embryos, but not in adults.
Dr. Brian Koffman, a well-known doctor, educator, and clinical professor turned patient has dedicated himself to teaching and helping the CLL community since his diagnosis in 2005. He serves as the Executive Vice President and Chief Medical Officer of the CLL Society Inc.
Originally published in The CLL Tribune Q2 2019.