Ask the Doctor Question: I have to start my first therapy soon and living in Germany. First diagnosis in 2015 and until now, watch and wait. ighv mutated, trisomie12, birc3 mutation. WBC 60,000, platelets 100,000, Hämoglobin 10,5. Does acalabrutinib work in the birc3 mutation? Or is venetoclax obinutuzumab better?