Minimal Residual Disease Assessment in CLL: Ready for Use in Clinical Routine?
The methodologies for testing MRD are evolving and finding less than 1 in 10,000 cells by flow cytometry is today’s standard definition for undetectable minimal or measurable residual disease (uMRD). There is good reason to believe that the deeper levels achievable with next generation gene sequencing (NGS), capable of finding a single cancer cell in a million cells, may be even more valuable, especially with cellular therapies such as CAR-T and transplants.