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Medication Overview

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FEATURE

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ADDITIONAL READING

February 6, 2023

ASH 2022: Dr. Parag Jasani on NVG-111, a ROR1 Targeting Bispecific T Cell Engager, for Chronic Lymphocytic Leukemia (CLL)

Our own Dr. Brian Koffman interviewed Dr. Parag Jasani, a consultant hematologist with Royal Free London NHS Trust and University College London Hospitals. They discussed a first-in-human study of an experimental drug, NVG-111, a bispecific T cell engager. NVG-111 binds to ROR1 on cancer cells and CD3 on T

January 6, 2023

ASH 2022: Dr. Christine Ryan on Triple Combination Acalabrutinib, Venetoclax, and Obinutuzumab for High-Risk Patients with Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma (CLL/SLL)

In this ongoing trial, the triple combination therapy with acalabrutinib, venetoclax, and obinutuzumab is highly active and has thus far produced durable remissions as a frontline treatment in patients with TP53-aberrant chronic lymphocytic leukemia (CLL), which was generally well tolerated with a low 2.9% incidence of atrial fibrillation with

November 18, 2022

Obinutuzumab/Acalabrutinib/Venetoclax Combo Misses the Mark for MRD in Advanced Chronic Lymphocytic Leukemia (CLL)

The combination of obinutuzumab (Gazyva), acalabrutinib (Calquence), and venetoclax (Venclexta) failed to meet the pre-specified rate of undetectable measurable or minimal residual disease (uMRD) following optimal debulking with bendamustine in patients with relapsed/refractory chronic lymphocytic leukemia (CLL).

October 12, 2022

ASH 2021: MAJIC – A Phase 3 Prospective, Multicenter, Randomized, Open-Label Trial of Acalabrutinib Plus Venetoclax Versus Venetoclax Plus Obinutuzumab in Previously Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

In summary, the results of MAJIC will help to inform the selection of time-limited doublet therapy approaches for patients with CLL/SLL and help define the duration of venetoclax in combination with either acalabrutinib or obinutuzumab.

September 22, 2022

ASH 2021: Most ASH Abstracts Reporting Phase II Studies Lead to Peer-Reviewed Publications, but Less Than 50% of “Positive” Abstracts Lead to Phase III Investigations: An Analysis of 371 Abstracts 2013 – 2015

Dr. David Cucchi and colleagues presented this research at the American Society for Hematology annual meeting, which was held in December 2021 (ASH 2021).

September 22, 2022

ASH 2021: Trial in Progress: Phase 1/2 Study Evaluating the Safety and Efficacy of IOV-2001, an Autologous, Non-Genetically Modified, Polyclonal T-Cell Product, in Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL)

Dr. Javier Pinilla Ibarz and colleagues presented this research at the American Society for Hematology annual meeting, which was held in December 2021 (ASH 2021).

Treatment and Research

Relapsed/Refractory or Later Therapies

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RECENT NEWS

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ASH 2022: Dr. Nirav Shah on Pirtobrutinib for Richter Transformation

ASH 2022: Dr. Matthew Davids on the Contribution of Obinutuzumab to Acalabrutinib Therapy in Patients with Chronic Lymphocytic Leukemia or Small Lymphocytic Leukemia (CLL/SLL)

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Medication Overview

Action items for Medication Overview

Action item one

Action item two

Action item three

FEATURE

TBD - will add after article migration

ADDITIONAL READING

ASH 2022: Dr. Parag Jasani on NVG-111, a ROR1 Targeting Bispecific T Cell Engager, for Chronic Lymphocytic Leukemia (CLL)

ASH 2022: Dr. Christine Ryan on Triple Combination Acalabrutinib, Venetoclax, and Obinutuzumab for High-Risk Patients with Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma (CLL/SLL)

Obinutuzumab/Acalabrutinib/Venetoclax Combo Misses the Mark for MRD in Advanced Chronic Lymphocytic Leukemia (CLL)

ASH 2021: MAJIC – A Phase 3 Prospective, Multicenter, Randomized, Open-Label Trial of Acalabrutinib Plus Venetoclax Versus Venetoclax Plus Obinutuzumab in Previously Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

ASH 2021: Most ASH Abstracts Reporting Phase II Studies Lead to Peer-Reviewed Publications, but Less Than 50% of “Positive” Abstracts Lead to Phase III Investigations: An Analysis of 371 Abstracts 2013 – 2015

ASH 2021: Trial in Progress: Phase 1/2 Study Evaluating the Safety and Efficacy of IOV-2001, an Autologous, Non-Genetically Modified, Polyclonal T-Cell Product, in Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL)

RECENT NEWS

ASH 2022: Dr. Nirav Shah on Pirtobrutinib for Richter Transformation

ASH 2022: Dr. Matthew Davids on the Contribution of Obinutuzumab to Acalabrutinib Therapy in Patients with Chronic Lymphocytic Leukemia or Small Lymphocytic Leukemia (CLL/SLL)

CLL Society’s COVID-19 Update for the Week of February 6, 2023

USA Today Links the Immunocompromised to CLL Society’s COVID-19 Action Plan

CLL Society Organizes Joint Effort Urging Government Agencies to Focus on Continued COVID-19 for the Immunocompromised

CLL Society’s COVID-19 Update for the Week of January 30, 2023

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