Patients with CLL who had genetic testing before starting treatment were more likely to have better clinical outcomes than patients who were not tested.”
Real-world data shows that venetoclax-based therapy is associated with better outcomes in older patients with CLL compared with covalent BTK inhibitors.
In an early-stage clinical trial, half of patients with relapsed / refractory Richter transformation responded to treatment with BTK degrader BGB-16673.
After patients with CLL were treated with venetoclax-obinutuzumab, their immune systems gradually recovered, but this was slower in patients with deep responses.
Preclinical research shows that rocbrutinib inhibits BTK and B-cell receptor pathway signaling even in the presence of BTK mutations commonly seen in CLL.
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