Immunotherapy
Immunotherapy works by harnessing the body’s own immune system and offers options for powerful, yet well-tolerated, therapies. Examples include monoclonal antibodies (rituximab, obinutuzumab, and others) that recognize the cancer, drugs that modulate the immune system, and others that take the brakes off of the immune system. These drugs are often combined with other types of therapy.
ARTICLES ON IMMUNOTHERAPY
With the introduction of BTK inhibitors to treat CLL, there has been no disparity in survival outcomes for patients of different races and ethnicities.
This should not be part of anyone’s game plan. Still, it was nice to read that for at least this one 67-year-old asymptomatic CLL patient, a case of COVID-19 associated with low blood counts and a broad spectrum of treatments resulted in his CLL becoming undetectable in his bone
Immunotherapy for chronic lymphocytic leukemia/small lymphocytic lymphoma or CLL / SLL holds the promise of harnessing the body’s immune system to recognize and eliminate cancer.
Also during ASH 2019, Dr. Koffman interviewed Dr. Adrian Wiestner, who discussed bi-specific antibodies to improve the immune system in CLL patients. There is reason to believe that when used in combination with a BTK inhibitor such as ibrutinib, they would have increased effectiveness, as ibrutinib improves T cell
Dr. Brian Koffman interviewed Dr. Krish Patel at ASH 2019, about how our native immune system is excellent at controlling cancer when it is working normally. In CLL, the immune system has become dysregulated and does a poor job controlling cancer. Could modifying the immune system with off-the-shelf bi-specific
The ECOG (E1912) Phase III, randomized, open label, clinical trial, comparing the efficacy of combination ibrutinib and rituximab with standard chemo-immunotherapy (FCR in patients 70 years of age or younger with previously untreated CLL) was a huge game-changer for CLL patients. We are happy to share with you Dr.
RECENT NEWS
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