Targeted Therapies

Most new “small molecules” can be taken by mouth. Many work by blocking pathways that the cancer cells have pirated and become addicted to such as signaling pathways. Examples include ibrutinib, acalabrutinib, duvelisib and others. Others, such as venetoclax, remove blockades that the cancer has created which prevent natural cell death. These therapies target the cancer and spare most healthy cells.

ARTICLES ON TARGETED THERAPIES

Pushing Therapeutic Boundaries in CLLJoint Live Web Broadcast with CLL Society and PeerView Institute Recorded on June 14, 2021 Continuous or fixed-duration therapy with targeted agents, including BTK and BCL-2 inhibitors, is the new standard for management of chronic lymphocytic leukemia (CLL). New clinical questions that are pushing the