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The World’s Leading Authority for Chronic Lymphocytic Leukemia Patients

Clinical Trials

CLL is not a solved problem, but we do have excellent treatments. It was only through clinical trials that the safety and efficacy of existing therapies was proven, and the only means by which any new therapies will become available.

Clinical trials are critical for the development of new methods to prevent, detect, and treat cancer. Within clinical trials, researchers determine whether new treatments are safe and effective and work better than current treatments. Participating in a clinical trial may also offer the opportunity to gain access to newer or more treatment options and possibly save some of the cost of medications. However there could be some undiscovered risks and downsides. Clinical trial inclusion and exclusion criteria determine whether you would be eligible for a specific trial. Most people first hear about clinical trials from their doctors, but you can search for clinical trials online on your own to explore what might be a good option. Discussing a potential trial would be part of the shared decision-making process you have with your CLL team.

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Action Items for Clinical Trials

Visit these 4 links for in-depth information and articles.

This is where you can learn the basics about clinical trials, including FAQs, trial phases, how to navigate Clinicaltrials.gov, and much more.

The latest news about the opening, closing, important amendments, holds, and other regulatory news is found here.

The published results of many of the trials that help us better manage CLL/SLL will be posted here. Even more might be found on the website under the various subjects that the trial was studying such as COVID-19, Richter’s Transformation, or Relapsed/Refractory CLL/SLL.

Benefit from the real-world experience of fellow patients and caregivers as they share what they learned from participating in clinical trials.

This is where you can learn the basics about clinical trials, including FAQs, trial phases, how to navigate Clinicaltrials.gov, and much more.

The latest news about the opening, closing, important amendments, holds, and other regulatory news is found here.

The published results of many of the trials that help us better manage CLL/SLL will be posted here. Even more might be found on the website under the various subjects that the trial was studying such as COVID-19, Richter’s Transformation, or Relapsed/Refractory CLL/SLL.

Benefit from the real-world experience of fellow patients and caregivers as they share what they learned from participating in clinical trials.

FEATURE

Clinical Trials: Frequently Asked Questions (FAQ)

Considering a clinical trial may seem like a daunting prospect, but sometimes it can be the smartest strategy. Here are some basic questions to help you make a good decision.

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ADDITIONAL READING

MS-553, a protein kinase C-beta (PKCß) inhibitor, is an exciting new agent in a yet-to-be-approved class of drugs that target an area of the B-cell receptor pathway independent of Bruton tyrosine kinase (BTK) and phospholipase C gamma 2 (PLCy2) mutations which confer resistance to BTK inhibitors.
In this ongoing trial, the triple combination therapy with acalabrutinib, venetoclax, and obinutuzumab is highly active and has thus far produced durable remissions as a frontline treatment in patients with TP53-aberrant chronic lymphocytic leukemia (CLL), which was generally well tolerated with a low 2.9% incidence of atrial fibrillation with