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and President, interviewed Dr. Alexey Danilov, Associate Director of the Toni Stephenson Lymphoma Center at City of Hope in Duarte, CA. They discussed the development of Richter transformation after chimeric antigen receptor T-cell (CAR-T) therapy.
Dr. Mato and Dr. Woyach discusses the results of a study looking at which features might predict the future development of Richter’s syndrome in patients treated with ibrutinib.
Richter’s Transformation Richter’s Transformation First described in 1928, Richter’s Transformation (RT), also called Richter’s Syndrome (RS), occurs when CLL / SLL changes into a related but much more aggressive large cell
This research was presented by Dr. Romain Guieze and colleagues at the American Society for Hematology annual meeting which was held December 2021 (ASH 2021).
Ask the Doctor Question: What prognostic value is exon 15 braf mutation discovery with no tp53, no 17p, no trisonomy 12, no del 11q, but Unmutated status? Am I in line
At the annual meeting of the European Hematology Association (EHA) 2021, our own Dr. Brian Koffman interviewed Dr. Anthony Mato, Director of the CLL Program at Memorial Sloan Kettering Cancer Center. They discussed preliminary results from a clinical trial of pirtobrutinib (formerly LOXO-305) in a subset of patients with Richter’s transformation.
ASH 2020: Dr. Arnon Nagler on Safety and Efficacy of CD19-CAR T Cells in Richter’s Transformation After Targeted Therapy for Chronic Lymphocytic Leukemia (CLL)
CLL Society On Demand Ed Forum: ASH 2020 Comes to You – Session 3: New Combinations, New Sequences, New Ways to Measure Disease + CAR-T for Richters Recorded Thursday, February 4,
This clinical trial introduces the concept of “synthetic lethality,” where multiple targeted agents are used at low dosages to block different pathways, and achieve the ability to kill cancer cells without the associated toxicities of using three drugs together at their usual dosages.
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