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January 2024 CLL Bloodline

In science and medicine, information is constantly changing and may become out-of-date as new data emerge. All articles and interviews are informational only, should never be considered medical advice, and should never be acted on without review with your health care team.

Happy New Year! Over a year of monthly meetings, The CLL Society Bloodline will teach the basics needed to understand CLL, starting with definitions and diagnoses this month. It will also provide news, help with acronyms and new vocabulary words, and offer simple, fun quizzes. The cycle just restarted and is updated yearly. If you are new to CLL / SLL, expect to learn many new words and acronyms and even to be overwhelmed at first, but it does get much easier over time.

MONTHLY QUIZ (same old silly quiz): Neutrophils are:

  1. A type of immature white blood cell.
  2. Important in preventing bruising or bleeding.
  3. A white blood cell important in fighting infections.
  4. The blood cells that, when they become malignant, cause CLL.
  5. Blood cells were first discovered in Switzerland, a neutral country.

The correct answer is 3. Neutrophils, or “neuts,” are the most common white blood cell in the body and are critical in fighting infections, especially bacterial ones. They are also involved in inflammation and are the primary cells found in pus. If we have too few neuts, a low absolute neutrophil count (ANC) called neutropenia from CLL, or medications such as chemo or venetoclax, we may be at risk of severe infections. They are called neutrophils because their granules stain neutral under the microscope.

NEWS: On 12/1/2023, the FDA granted accelerated approval to pirtobrutinib (Jaypirca) for adults with chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL / SLL) who have received at least two prior lines of therapy, including a BTK inhibitor and a BCL-2. This gives CLL / SLL patients a welcome new option after failing a covalent BTKi (ibrutinib, acalabrutinib or zanubrutinib) and venetoclax.

At the most important blood cancer conference of the year, the annual meeting of the American Society of Hematology (ASH) 2023, there was no revolutionary changes, but there were data that zanubrutinib continues to offer improved efficacy and fewer side effects than ibrutinib after 3 years and encouraging results on use of pirtobrutinib in relapsed/refractory CLL / SLL and Richter’s Transformation. For more information, please join us for our upcoming webinar on important ASH 2023 research with Dr. Nicole Lamanna at 1 PM PT 4 PM ET on January 29th. It will be very informative. ASH interviews and articles will also be coming soon on the website.

COVID-19 continues to be a problem for CLL / SLL patients who are all immunocompromised. No effective monoclonal antibodies are now authorized for treatment, though several are in development. Paxlovid, remdesivir, and molnupiravir all remain effective life-saving treatments with lower mortality rates reported.

THE BASICS: Definitions and Diagnosis. CLL is a slow-growing or “indolent” or “chronic” leukemia/ lymphoma of the B-lymphocytes, a subtype of white blood cells and an essential part of our immune system. CLL is leukemia because it’s found in the blood, and lymphoma because it arises from a lymphocyte. It can be found in the peripheral blood, bone marrow, and lymph tissue, including the lymph nodes and the spleen, and rarely in other organs, such as the liver, kidneys, and even the brain and lungs. SLL (small lymphocytic lymphoma) is the same disease that has not significantly spilled over into the blood. CLL / SLL is a cancer of the B cells involved in making antibodies. CLL is diagnosed by finding ≥5000 clonal (genetically identical) B lymphocytes in the blood for at least three months. SLL, where there are fewer than 5000 monoclonal B lymphocytes in the blood, is usually diagnosed when an enlarged lymph node is biopsied, and the same type of cells found in the bloodstream with CLL are seen in the biopsied node. The clonal nature of the B lymphocytes should be confirmed by flow cytometry, a test that identifies specific surface markers on the cell, a sort of immune fingerprint. A bone marrow biopsy and imaging such as CT or PET scans are rarely needed to make the diagnosis and should not be routinely done at diagnosis without a good reason.

WORD/ACRONYM OF THE MONTH: Clone. A group of genetically identical cells that originates from a single parent cell. For example, leukemia cells develop from one original abnormal cell. CLL is a clonal cancer, though to confuse things, one may have several sub-clones of CLL that fight for dominance and respond differently to treatment. That is why combinations of drugs are sometimes used in therapy to wipe out all the subclones.

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