Zanubrutinib Approved in the U.S. for Chronic Lymphocytic Leukemia/ Small Lymphocytic Lymphoma (CLL / SLL)
With the FDA’s approval of zanubrutinib, CLL / SLL patients have another very strong choice to manage their disease.
With the FDA’s approval of zanubrutinib, CLL / SLL patients have another very strong choice to manage their disease.
In this ongoing trial, the triple combination therapy with acalabrutinib, venetoclax, and obinutuzumab is highly active and has thus far produced durable remissions as a frontline treatment in patients with TP53-aberrant chronic lymphocytic leukemia (CLL), which was generally well tolerated with a low 2.9% incidence of atrial fibrillation with none of the more serious abnormal ventricular heart irregularities seen.
WOULD YOU LIKE TO PARTICIPATE IN A DISCUSSION ABOUT CLL / SLL?
WE ARE RECRUITING PARTICIPANTS TO TAKE PART IN A ONE-ON-ONE INTERVIEW ABOUT CLL / SLL
Dr. Susan Leclair has reviewed three abstracts from the 2021 American Society of Hematology Annual Meeting and Exposition, or ASH 2021, on chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL / SLL) patients’ responses to vaccines, two on the COVID-19 vaccine, and one on the shingles vaccines.
Many chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL / SLL) patients are insured under Medicare – either Original Medicare with a drug plan (Part A, B, and D “a la carte”) or a Medicare Advantage Plan (including Parts A, B, and D Prix fixe). Unfortunately, over the past several years, drug costs have risen significantly for targeted oral anti-cancer drugs.
It is much too early to predict how lisaftoclax will fit into the treatment paradigm for chronic lymphocytic leukemia/small lymphocytic lymphoma. Still, right now, it looks very similar to venetoclax, with the possible advantage of a faster ramp-up to the treatment dose
In this interview, our own Dr. Brian Koffman spoke with Dr. Michael Joyner, an anesthesiologist at the Mayo Clinic in Rochester, MN. They discussed the use of convalescent plasma to treat COVID-19.
In summary, the results of MAJIC will help to inform the selection of time-limited doublet therapy approaches for patients with CLL / SLL and help define the duration of venetoclax in combination with either acalabrutinib or obinutuzumab.
Dr. Javier Pinilla Ibarz and colleagues presented this research at the American Society for Hematology annual meeting, which was held in December 2021 (ASH 2021).
© 2025 CLL Society. All Rights Reserved.
Legal | Privacy Policy | Corporate Giving Policy
Terms & Conditions | Report a Bug | Site Design
CLL Society Inc. is a patient–centric, physician–curated nonprofit organization focused on patient education, support, and research. Dedicated to addressing the unmet needs of the chronic lymphocytic leukemia (CLL) and related blood cancer communities, we explain the rapidly changing therapeutic landscape and the importance of clinical trials, support and build patient networks, engage in research, and educate providers and patients.
CLL Society is a registered 501(c)(3) tax-exempt nonprofit organization. All donations are tax-deductible to the greatest extent as allowed under federal law. CLL Society’s tax ID number is 46-4131354.
1454 Melrose Avenue, Ste. 1-247
Chula Vista, CA 91911
Cookie | Duration | Description |
---|---|---|
cookielawinfo-checkbox-analytics | 11 months | This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Analytics". |
cookielawinfo-checkbox-functional | 11 months | The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional". |
cookielawinfo-checkbox-necessary | 11 months | This cookie is set by GDPR Cookie Consent plugin. The cookies is used to store the user consent for the cookies in the category "Necessary". |
cookielawinfo-checkbox-others | 11 months | This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other. |
cookielawinfo-checkbox-performance | 11 months | This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Performance". |
viewed_cookie_policy | 11 months | The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. It does not store any personal data. |