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Richter’s Transformation (RT) or Richter’s Syndrome (RS) remains a major unmet need in CLL. For a background on RT, please read this article by Dr. Weistner from the National Institutes of
By Brian Koffman, MD and Anthony Mato, MD As we are getting better at controlling CLL and living longer, there is increasing concern about serious late complications including Richter’s Transformation (RT)
In 1928, Dr. Richter described a patient with chronic lymphocytic leukemia (CLL), who progressed to develop an aggressive large cell lymphoma. Richter syndrome (RS), also called Richter transformation, is now understood to describe the development of an aggressive lymphoma in patients with CLL or small lymphocytic lymphoma (SLL).
CLL Society awarded Dr. Prajish Iyer a research grant for his project studying Richter’s transformation, a rare but aggressive progression of CLL.
Over the course of a year of monthly meetings, The CLL Society Bloodline will teach the BASICS needed to understand CLL. It will also provide news, help with the acronyms and new vocabulary words, and offer simple fun quizzes. The cycle restarts and it is updated annually.
Though it is still very early on, BTK degrader BGB-16673 appears tolerable. Clinical trials of BTK degraders may be especially of interest to CLL patients
MRD guided acalabrutinib, venetoclax and obinutuzumab led to an 88% progression free survival rate in relapsed / refractory chronic lymphocytic leukemia.
A new phase 3 clinical trial is testing sonrotoclax, a new BCL2 inhibitor, in combination with zanubrutinib for CLL.
Chimeric antigen receptor T-cell (CAR-T) therapy can provide durable remissions in a subset of patients with Richter’s transformation.
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