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Ask the Pharmacist: Drug interactions between CLL drugs and discussed hydroxychloroquine/Z-pack combo possibly for COVID-19

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Any known contraindication to taking the much discussed hydroxyclhoroquine/Z-pack combo with Ibrutinib if I as a CLL patient contract covid19? As I understand it had been used to treat malaria as well as rheumatoid arthritis. I also recall Ibrutinib was initially developed to treat rheumatoid arthritis.


Here is the answer from Tom henry, our pharmacist.

I performed a drug interaction check on the most commonly used oral CLL drugs ibrutinib, acalabrutinib, venetoclax, duvelisib and idelalisib in combination with both hydroxychloroquine and azithromycin (Z-Pak). The only interactions were with idelalisib or duvelisib and hydroxychloroquine.

There is also a potential interaction between hydroxychloroquine and azithromycin with an increased risk of heart irregularities.