Sonrotoclax and Zanubrutinib as a Frontline CLL Treatment
The combination of sonrotoclax and zanubrutinib was well-tolerated and produced high rates of undetectable disease in patients with treatment-naïve CLL.
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The combination of sonrotoclax and zanubrutinib was well-tolerated and produced high rates of undetectable disease in patients with treatment-naïve CLL.
Combining the new BCL2 inhibitor sonrotoclax with the BTK inhibitor zanubrutinib produced an overall response rate of 97% in relapsed CLL / SLL.
The combination therapy of tislelizumab plus zanubrutinib is effective and well-tolerated for patients with Richter’s transformation.
Zanubrutinib may be taken alone as a preferred initial (first-line) treatment, or alone as a second- or third-line treatment.
A Matching-Adjusted Indirect Comparison (MAIC) Case Study: Zanubrutinib vs. Acalabrutinib Education Activity
Zanubrutinib is an excellent option for patients with CLL / SLL who are unable to tolerate acalabrutinib due to side effects.
Early data on combination sonrotoclax plus zanubrutinib for previously untreated CLL / SLL is very promising.
Most resistance mutations acquired by CLL patients during zanubrutinib treatment occurred at a single site on BTK.
A new phase 3 clinical trial is testing sonrotoclax, a new BCL2 inhibitor, in combination with zanubrutinib for CLL.
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