Predicting Which CLL Patients May Respond to CAR-T Therapy
Lisocabtagene Maraleucel (liso-cel), a CAR-T therapy, is effective but only in a minority of chronic lymphocytic leukemia (CLL) patients.
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Lisocabtagene Maraleucel (liso-cel), a CAR-T therapy, is effective but only in a minority of chronic lymphocytic leukemia (CLL) patients.
CAR-T therapy is a potent cellular immune treatment that genetically trains an individual’s immune system to both recognize and attack cancerous cells.
An experimental CAR-T cell therapy made from healthy donor T cells is being tested in an ongoing phase 1 clinical trial to treat B Cell cancers.
Chimeric Antigen Receptor T-cell (CAR-T) therapy is a potent cellular immune treatment that genetically trains an individual’s immune system (specifically, the T-cells, a type of white blood cell) to both recognize and attack cancerous cells.
Chimeric antigen receptor T-cell (CAR-T) therapy can provide durable remissions in a subset of patients with Richter’s transformation.
Chimeric antigen receptor T-cell (CAR-T) therapy can provide durable remissions in a subset of patients with Richter’s transformation.
This research shows that senescence (biological aging) can occur in CAR-T cells, reducing their ability to kill cancer cells.
and President, interviewed Dr. Alexey Danilov, Associate Director of the Toni Stephenson Lymphoma Center at City of Hope in Duarte, CA. They discussed the development of Richter transformation after chimeric antigen receptor T-cell (CAR-T) therapy.
CAR-T therapy is a revolutionary therapy that trains the patient’s own cells to attack their CLL / SLL. The science can be somewhat complicated and advanced, but the results can be amazing. You
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