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Search Results for: Measurable Residual Disease Testing – Page 3

Minimal Residual Disease Assessment in CLL: Ready for Use in Clinical Routine?

The methodologies for testing MRD are evolving and finding less than 1 in 10,000 cells by flow cytometry is today’s standard definition for undetectable minimal or measurable residual disease (uMRD). There is good reason to believe that the deeper levels achievable with next generation gene sequencing (NGS), capable of finding a single cancer cell in a million cells, may be even more valuable, especially with cellular therapies such as CAR-T and transplants.

Dr. Nitin Jain Explains MRD testing by FLOW Cytometry

At ASH 2019 in Orlando, FL, Dr. Nitin Jain explained MRD testing for “minimal” or “measurable” residual disease, which may soon become recognized as the most reliable indicator of whether or when patients might have attained such a low level of disease that treatment could be discontinued (“limited” or “fixed” duration). Dr. Jain’s explanation cites MRD testing by FLOW Cytometry (testing down to 1 CLL cell in a sample of 10,000 cells).

ASH 2022: Final Analysis of the Prospective Multicenter CLL2-Give Trial of Obinutuzumab, Ibrutinib, and Venetoclax in Untreated Patients with CLL with 17p Deletion/TP53 Mutation

Fixed duration combination therapy of obinutuzumab, ibrutinib, and venetoclax with treatment adjustment based on clinical response and results of measurable residual disease testing shows high efficacy and safety for the front-line treatment of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL / SLL) patients with del (17p) or TP53 mutation offering exciting hope for what has been an unmet need for this group of patients with high-risk disease.

TARGETED ORAL TREATMENT OPTIONS

Targeted oral treatment options for CLL and SLL are medications taken by mouth that identify and attack specific cancer cells.

IMAGING TESTS

A variety of tests are used to capture images inside the body when chronic lymphocytic leukemia (CLL) and small
lymphocytic lymphoma (SLL) are present. Imaging tests are used to look inside the body to capture pictures that will help the healthcare team visualize what, if any, internal changes might be occurring.

CLINICAL TRIALS

A clinical trial for those living with CLL and SLL is a carefully controlled research study to improve the overall care and treatment.

Clinicians

Clinician Resource Library: Informational Handouts Click below on each of the topical handouts to view and print copies on demand. You may also order a free Welcome Kit which includes a

Staging

Staging in cancer is a process used to determine the extent to which cancer has spread in the body, predict its progression, and guide treatment decisions.

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