Richter's Transformation
Richter's Transformation
First described in 1928, Richter’s Transformation (RT), also called Richter’s Syndrome (RS), occurs when CLL / SLL changes into a related but much more aggressive large cell lymphoma in patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL).
Often, the transformation is into diffuse large B-cell lymphoma (DLBCL), but other lymphomas are seen, including Hodgkin’s lymphoma which generally has a better prognosis.
As patients with CLL / SLL are living longer, the long-term risk of developing RT is increasing. Most RT is fast moving, unlike CLL / SLL which is usually slow growing or indolent. RT demands quick intervention. Richter’s Transformation is difficult to treat and remains one of the most significant unmet needs in CLL.
A clinical trial is often the best choice for Richter’s Transformation.
Action Item for Richter’s Transformation
Find a clinical trial.
A clinical trial is often the best choice for Richter’s Transformation. Begin by looking at our Additional Reading below.
Find a clinical trial.
A clinical trial is often the best choice for Richter’s Transformation. Begin by looking at our Additional Reading below.
FEATURE
Role of Stem Cell Transplants in Richter’s Transformation
Richter’s transformation is a rare and very aggressive complication of chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL), where the disease turns into a much more aggressive lymphoma, usually diffuse large B cell lymphoma (DLBCL). Haemopoietic (blood forming) stem cell transplants (HSCT) are one of the only successful therapies for Richter’s transformation, but they are rarely used. In this interview, Dr. Brian Koffman spoke with Dr. Adam Kittai, an associate professor of medicine at Mount Sinai. They discussed the role of haemopoietic stem cell transplants in treating Richter’s transformation.
ADDITIONAL READING
RECENT NEWS
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NEWLY DIAGNOSED
LIST OF CLL DOCTORS
NORMAL LAB VALUES
TESTING AND IMAGING
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ABBREVIATIONS AND GLOSSARY
FREE CLL EXPERT OPINION
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