Richter's Transformation
Richter's Transformation
First described in 1928, Richter’s Transformation (RT), also called Richter’s Syndrome (RS), occurs when CLL / SLL changes into a related but much more aggressive large cell lymphoma in patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL).
Often, the transformation is into diffuse large B-cell lymphoma (DLBCL), but other lymphomas are seen, including Hodgkin’s lymphoma which generally has a better prognosis.
As patients with CLL / SLL are living longer, the long-term risk of developing RT is increasing. Most RT is fast moving, unlike CLL / SLL which is usually slow growing or indolent. RT demands quick intervention. Richter’s Transformation is difficult to treat and remains one of the most significant unmet needs in CLL.
A clinical trial is often the best choice for Richter’s Transformation.
Action Item for Richter’s Transformation
Find a clinical trial.
A clinical trial is often the best choice for Richter’s Transformation. Begin by looking at our Additional Reading below.
Find a clinical trial.
A clinical trial is often the best choice for Richter’s Transformation. Begin by looking at our Additional Reading below.
FEATURE
CAR T Therapy for Richter's Transformation
The Bottom Line:
CAR-T therapy can be effective in certain patients with Richter transformation. Patients who respond to CAR-T therapy are more likely to have durable remissions.
Who Performed the Research and Where Was it Presented:
Dr. Paolo Ghia from Università Vita-Salute San Raffaele in Milano, Italy, and colleagues presented the results at the American Society for Hematology (ASH) Annual Meeting 2024.
ADDITIONAL READING
RECENT NEWS
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NEWLY DIAGNOSED
LIST OF CLL DOCTORS
NORMAL LAB VALUES
TESTING AND IMAGING
ASK THE EXPERTS
ABBREVIATIONS AND GLOSSARY
FREE CLL EXPERT OPINION
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