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Do the test results just indicate the presence/absence of antibodies, or do they also indicate a quantitative degree of antibody response (e.g., 65% positive response)?

Ask the Doctor Question:

I saw in a previous CLL Society Alert that if you were considering getting a COVID-19 antibody test, to make sure that it was a Spike protein test. I have been vaccinated (Moderna in late February/March) and would like to get an antibody test. Do the test results just indicate the presence/absence of antibodies, or do they also indicate a quantitative degree of antibody response (e.g., 65% positive response)?

Answer: The Spike antibody test is semi-quantitative with ranges measuring from 0‑2,500. If your range is >0.80 you have measurable antibodies. The problem is that no one knows what number equates to protective immunity for CLL patients, if any at all, or if a detectable level of antibodies means you have immunity.

It’s important to remember that because of the highly infectious Delta variant that is now in our midst as well as the vast majority of those around us now unmasking, it is more important than ever for CLL patients to wear a tightly fitted facemask (preferably a N-95) if there is a need to be around others, maintain social distancing, practice good handwashing, and avoid all crowded situations. It’s not the news we want to hear, but we need to remain diligent while we are still in the midst of a pandemic.

Stay closely tuned to our website, as we will post any new information we have as soon as it is released to the public. We anticipate there being more information coming out soon as a result of numerous research efforts that are looking into this very issue.