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Is it normal for the WBC to decrease at times on its own, and why?

Ask the Doctor Question:

Is it normal for the WBC to decrease at times on its own, and why?

Answer: Yes, it is normal to have fluctuations, even for those without CLL. It can be dependent upon a number of external factors as well. For instance, even something as minor as the time of day the blood sample was drawn, or differences can also occur based on what lab ran the sample.