Clinical Trial Results

May 2, 2023

ASH 2022: Dr. Mazyar Shadman on Enitociclib, a CDK9 Inhibitor, for Non-Hodgkin Lymphoma (NHL) and Chronic Lymphocytic Leukemia (CLL)

We discuss enitociclib, an experimental CDK9 inhibitor in development for treating NHL and CLL.

February 15, 2023

ASH 2022: Dr. James Blachly Discusses Results from a Phase 1/2 Dose Escalation and Expansion Study Evaluating MS-533, a Novel and Selective Protein Kinase C-Beta Inhibitor in Patients with Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL)

MS-553, a protein kinase C-beta (PKCß) inhibitor, is an exciting new agent in a yet-to-be-approved class of drugs that target an area of the B-cell receptor pathway independent of Bruton tyrosine kinase (BTK) and phospholipase C gamma 2 (PLCy2) mutations which confer resistance to BTK inhibitors.

February 6, 2023

ASH 2022: Dr. Parag Jasani on NVG-111, a ROR1 Targeting Bispecific T Cell Engager, for Chronic Lymphocytic Leukemia (CLL)

Our own Dr. Brian Koffman interviewed Dr. Parag Jasani, a consultant hematologist with Royal Free London NHS Trust and University College London Hospitals. They discussed a first-in-human study of an experimental drug, NVG-111, a bispecific T cell engager. NVG-111 binds to ROR1 on cancer cells and CD3 on T

March 30, 2022

ASH 2021: Dr. Bill Wierda Discusses Outcomes of Adding Oral Venetoclax (Ven) to Patients with Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) Currently Receiving Oral Ibrutinib (Ibr).

At the annual meeting of the American Society of Hematology (ASH) 2021, Dr. Mathew Davids from the Dana-Farber Cancer Institute in Boston interviews Dr. Bill Wierda from the MD Anderson Cancer Center in Houston. They discuss the benefits of combined finite therapy to achieve U-MRD with a

February 24, 2022

ASH 2021: BRUIN CLL-321: A Phase 3 Open-Label, Randomized Study of Pirtobrutinib Versus Investigator’s Choice of Idelalisib Plus Rituximab or Bendamustine Plus Rituximab in BTK Inhibitor Pretreated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (Trial in Progress)

Dr. Jeff Sharman and colleagues presented this research at the American Society for Hematology annual meeting held December 2021 (ASH 2021).

February 16, 2022

ASH 2021: SEQUOIA: Results of a Phase 3 Randomized Study of Zanubrutinib versus Bendamustine plus Rituximab (BR) in Patients with Treatment Naive (TN) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL / SLL)

This abstract from the American Society of Hematology Annual Meeting and Exposition (ASH 2021) presented interim results of the Phase 3 randomized SEQUOIA study which evaluated the efficacy and safety of zanubrutinib versus BR in previously untreated chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL / SLL) patients without the high-risk mutation,17p deletion

March 1, 2021

ASH 2020: Dr. Paolo Ghia Discusses the ASCEND Study – Acalabrutinib vs. Idelalisib + Rituximab or Bendamustine + Rituximab in Relapsed or Refractory Chronic Lymphocytic Leukemia or CLL

During ASH 2020, Dr. Paolo Ghia discussed the ASCEND Study – Acalabrutinib vs. Idelalisib + Rituximab or Bendamustine + Rituximab in Relapsed or Refractory CLL. Dr. Ghia presented the final analyses of the ASCEND trial after nearly two years of follow-up. Acalabrutinib was the clear winner.

September 17, 2020

ASH 2019: Dr. Tam Discusses Captivate Trial – Ibrutinib + Venetoclax in First-Line Treatment

CLL is a smart cancer, but we are smarter. Dr. Tam at ASH 2019 talks about the outstanding results of the CAPTIVATE trial combining two great drugs, namely ibrutinib and venetoclax.

January 2, 2020

iwCLL 2019: Dr. Danielle Brander on Bendamustine and Rituxan (BR) versus Ibrutinib Based Therapies for Frontline Treatment of Chronic Lymphocytic Leukemia (CLL) in Elderly Patients

The phase III Alliance A041202 collaborative multi-centered trial demonstrated once and for all the superiority of ibrutinib versus Bendamustine/Rituximab (BR) when used frontline in older CLL patients. Dr. Brander from Duke fills in more details at iwCLL 2019 in Scotland.

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