Opening Trials & Status Updates

October 23, 2024

BTK Degrader Offers Promise in Relapsed and Refractory CLL

In heavily treated chronic lymphocytic leukemia patients who have poor prognoses and few options, the BTK degrader, NX-5948, was responsive.

October 11, 2024

BTK Degrader Demonstrates Safety for Relapsed and Refractory CLL

Blocking the BTK pathway transformed treatment for CLL, but resistance can develop. The BTK degrader destroys it with two-thirds of patients responding.

October 11, 2024

Sonrotoclax Plus Zanubrutinib Shows Deep Response in CLL

Combining the new BCL2 inhibitor sonrotoclax with the BTK inhibitor zanubrutinib produced an overall response rate of 97% in relapsed CLL / SLL.

June 27, 2024

Safety of Dual Covalent and Noncovalent BTK Inhibitor for CLL

LP-168 is a new dual covalent and noncovalent BTK inhibitor being tested in clinical trials to treat CLL. Initial results show it is well-tolerated.

June 20, 2024

A New Treatment Combination Being Studied for High-Risk CLL

A new phase 1 clinical trial is recruiting patients with relapsed / refractory CLL to test the safety of a combination of RP-3500 and olaparib.

June 17, 2024

Initial Study and Findings for BTK Degrader to Treat CLL

A new type of drug known as a BTK degrader is being studied in patients with chronic lymphocytic leukemia (CLL) and has promising early clinical data.

April 3, 2024

Phase 1 Study of BTK Degrader for B-Cell Cancers

Though it is still very early on, BTK degrader BGB-16673 appears tolerable. Clinical trials of BTK degraders may be especially of interest to CLL patients

April 3, 2024

Recruiting CLL Clinical Trial: ABBV-525, a MALT1 Inhibitor

A new clinical trial is recruiting patients with relapsed / refractory B-cell cancers to test the safety of a new experimental MALT1 inhibitor.

March 20, 2024

Recruiting Clinical Trial: Sonrotoclax Plus Zanubrutinib

A new phase 3 clinical trial is testing sonrotoclax, a new BCL2 inhibitor, in combination with zanubrutinib for CLL.

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