Ask the Doctor Question:
My IgHV results indicate the following:
Hypermutated
IgHV2-5.02
2% difference
What do the numbers after the IgHV mean (the 2-5.02)? What does the 2% difference mean?
Answer: Based on the information you shared your results appear to indicate that your IgHV status is MUTATED.
We know that patients with a “mutated” IgHV immunoglobulin do much better with FCR-based (chemoimmunotherapies) than those who are unmutated. Here are a couple of articles we have posted on the website that you might find helpful:
- https://cllsociety.org/2019/09/ash-2018-dr-nitin-jain-on-combining-ibrutinib-with-fludarabine-cyclophosphamide-and-obinutuzumab-for-igvh-mutated-cll-patients/
- https://cllsociety.org/2018/09/what-is-igvh-and-why-is-it-important/
- https://cllsociety.org/2020/01/iwcll-2019-dr-danielle-brander-on-bendamustine-and-rituxan-br-versus-ibrutinib-based-therapies-for-frontline-treatment-of-chronic-lymphocytic-leukemia-cll-in-elderly-patients/
