The combination of pirtobrutinib, venetoclax, and rituximab was very effective and produced deep remissions in patients with relapsed / refractory CLL.
Resistance mutations in BTK and PLCG2 are common in patients with CLL who progress on acalabrutinib, a BTK inhibitor treatment that is taken continuously.
Lenalidomide is an immunotherapy with promising efficacy for high-risk chronic lymphocytic leukemia (CLL). It appears safe with no increased infection risk.
Researchers studied first-line treatment with targeted therapies for patients with small lymphocytic lymphoma (SLL) and found they had durable remissions.
Though chronic lymphocytic leukemia (CLL) is rare in younger patients, adolescents and young adults with CLL have a better prognosis than older patients.
For patients with Richter’s transformation, the combination of ibrutinib, venetoclax, and obinutuzumab may be most useful as a bridge to other therapies.
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